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During the progression stage, H 2 O 2 is involved in the epithelial-to-mesenchymal transition (EMT) required for metastatic spread and the protumorigenic activity of tumor-associated macrophages, which participate in the formation of the tumor microenvironment

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Figure 2 Clinical Observations Four patients with NETs received investigational relacorilant as part of two clinical studies: a phase 2 Cushing syndrome study of relacorilant (NCT02804750, EudraCT 2016-000899-23) and a phase 1 oncology study of relacorilant + nab-paclitaxel (NCT02762981)